Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity

Author:

Amero Paola1ORCID,Lokesh Ganesh L. R.2,Chaudhari Rajan R.1,Cardenas-Zuniga Roberto1,Schubert Thomas3,Attia Yasmin M.14,Montalvo-Gonzalez Efigenia15ORCID,Elsayed Abdelrahman M.16ORCID,Ivan Cristina1,Wang Zhihui7ORCID,Cristini Vittorio7,Franciscis Vittorio de8910,Zhang Shuxing1,Volk David E.2,Mitra Rahul11,Rodriguez-Aguayo Cristian112ORCID,Sood Anil K.121311,Lopez-Berestein Gabriel11213

Affiliation:

1. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States

2. McGovern Medical School, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center, Houston, Texas 77030, United States;

3. 2bind GmbH, Am BioPark 11, Regensburg 93053, Germany

4. Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr Al Eini Street, Fom El Khalig, Cairo 11796, Egypt;

5. Integral Laboratory of Food Research, Technological Institute of Tepic, Avenue Tecnologico 2595, 63175 Tepic, Nayarit Mexico

6. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11675, Egypt

7. Mathematics in Medicine Program, The Houston Methodist Research Institute, 6670 Bertner Ave, Houston, Texas 77030, United States;

8. Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, 80131 Naples, Italy

9. National Research Council (CNR), Institute of Genetic and Biomedical Research (IRGB)-UOS Milan via Rita Levi Montalcini, 20090 Pieve Emanuele (MI), Italy

10. Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States

11. Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States;

12. Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States;

13. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States;

Funder

Division of Chemistry

National Cancer Institute

American Cancer Society

University of Texas MD Anderson Cancer Center

John P. Gaines Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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