Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis

Author:

Nicastri Michael C.1ORCID,Lehnherr Dan2ORCID,Lam Yu-hong3ORCID,DiRocco Daniel A.2,Rovis Tomislav1ORCID

Affiliation:

1. Department of Chemistry, Columbia University, New York, New York 10027, United States

2. Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference109 articles.

1. The importance of synthetic chemistry in the pharmaceutical industry

2. aJanssen Pharmaceutica NV. Farnesyl protein transferase inhibiting (imidazole-5-yl) methyl-2-quinolinone derivatives, their preparation, pharmaceutical compositions containing them and their preparation, and medicaments comprising them. Patent WO 9721701 A1, June 19, 1997.

3. bZhang, Y.; Hodous, B. L.; Kim, J. L.; Wilson, K.; Wilson, D. Compositions useful for treating disorders related to kit. Patent WO 2015057873 A1, October 15, 2014.

4. cKotian, P. L.; Babu, Y. S.; Kumar, V. S.; Zhang, W.; Vogeti, L. Preparation of pyrrolidinecarboxamide derivatives as human plasma kallikrein inhibitors. Patent WO 2017059178 A1, April 6, 2017.

5. dAdams, C. M.; Babu, C.; Capparelli, M. P.; Ding, J.; Ehara, T.; Jendza, K.; Ji, N.; Karki, R. G.; Kawanami, T.; Mainolfi, N.; Powers, J. J.; Serrano-Wu, M. H.; Xue, L.; Zhang, C. 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases. Patent WO 2014143638 A1, September 18, 2014.

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