Discovery of a Novel Dopamine Transporter Inhibitor, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone, as a Potential Cocaine Antagonist through 3D-Database Pharmacophore Searching. Molecular Modeling, Structure−Activity Relationships, and Behavioral Pharmacological Studies-Reference-Cited by-同舟云学术

Discovery of a Novel Dopamine Transporter Inhibitor, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone, as a Potential Cocaine Antagonist through 3D-Database Pharmacophore Searching. Molecular Modeling, Structure−Activity Relationships, and Behavioral Pharmacological Studies

Published:2000-01-19 Issue:3 Volume:43 Page:351-360
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Shaomeng¹,Sakamuri Sukumar¹,Enyedy Istvan J.¹,Kozikowski Alan P.¹,Deschaux Olivier¹,Bandyopadhyay Bidhan C.¹,Tella Srihari R.¹,Zaman Wahiduz A.¹,Johnson Kenneth M.¹

Affiliation:

1. Drug Discovery Program, Georgetown Institute for Cognitive and Computational Science, Georgetown University Medical Center, 3970 Reservoir Road, Washington, DC, 20007, Department of Pharmacology, Georgetown University Medical Center, 3970 Reservoir Road, Washington, DC, 20007, and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555-1031

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990516x

Reference54 articles.

1. Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

2. Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogs at the dopamine transporter

3. The dopamine hypothesis of the reinforcing properties of cocaine

4. Neurobiology of cocaine abuse

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