1. Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, New York 14260-1200, New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Sreet, Buffalo, New York 14203, and Baird Multiple Sclerosis Center and Department of Neurology, University at Buffalo, State University of New York, Amherst, New York 14260-1200