Exploiting the Therapeutic Potential of 8-β-d-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid β-Peptide (1

Exploiting the Therapeutic Potential of 8-β-d-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid β-Peptide (1–42)

Published:2014-11-12 Issue:22 Volume:57 Page:9463-9472
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jesus Ana R.¹,Dias Catarina¹,Matos Ana M.¹²,de Almeida Rodrigo F. M.¹,Viana Ana S.¹,Marcelo Filipa³,Ribeiro Rogério T.²⁴,Macedo Maria P.²⁴,Airoldi Cristina⁵,Nicotra Francesco⁵,Martins Alice¹,Cabrita Eurico J.³,Jiménez-Barbero Jesús⁶,Rauter Amélia P.¹

Affiliation:

1. Center of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, Faculdade de Ciências, Universidade de Lisboa, Ed C8, Piso 5, Campo Grande, 1749−016 Lisboa, Portugal

2. CEDOC Chronic Diseases Center, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Rua Câmara Pestana, 6, 6a, 1150-082, Lisboa, Portugal

3. REQUIMTE, CQFB, Department of Chemistry, Faculdade de Ciências e Tecnologias, Universidade Nova de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal

4. APDP, Diabetes Portugal Education and Research Center, APDP-ERC, Rua do Salitre, 118-120, 1250-203 Lisboa, Portugal

5. Department of Biotechnology and Biosciences, University Milano Bicocca, Piaza della Sciencia 2-4, 20126, Milano, Italy

6. Centro de Investigaciones Biológicas, C.S.I.C., Ramiro de Maeztu 9, 28040 Madrid, Spain

Funder

Directorate-General for Health and Consumers

European Commission

Ministerio de Economía y Competitividad

Fondazione Cariplo

Fundação para a Ciência e a Tecnologia

Fondo per la Promozione di Accordi Istituzionali

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501069h

Reference50 articles.

1. Protein Misfolding, Functional Amyloid, and Human Disease

2. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

3. Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

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