Impact of Mutation on Proton Transfer Reactions in Ketosteroid Isomerase: Insights from Molecular Dynamics Simulations
Author:
Affiliation:
1. Department of Chemistry, 104 Chemistry Building, Pennsylvania State University, University Park, Pennsylvania 16802
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja102714u
Reference78 articles.
1. NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase.
2. Solution Structure of 3-Oxo-Δ 5 -Steroid Isomerase
3. Asp-99 Donates a Hydrogen Bond Not to Tyr-14 but to the Steroid Directly in the Catalytic Mechanism of Δ5-3-Ketosteroid Isomerase from Pseudomonas putida Biotype B
4. Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole
5. Short, strong hydrogen bonds on enzymes: NMR and mechanistic studies
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