Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity-Reference-Cited by-同舟云学术

Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity

Published:2012-03-23 Issue:7 Volume:55 Page:3228-3241
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Innocenti Paolo¹,Cheung Kwai-Ming J.¹,Solanki Savade¹,Mas-Droux Corine²,Rowan Fiona¹²,Yeoh Sharon³,Boxall Kathy¹,Westlake Maura¹,Pickard Lisa¹,Hardy Tara³,Baxter Joanne E.³,Aherne G. Wynne¹,Bayliss Richard²³,Fry Andrew M.³,Hoelder Swen¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom

2. Chester Beatty Laboratories, Division of Structural Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom

3. Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester, LE1 9HN, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201683b

Reference22 articles.

1. Mitotic regulation by NIMA-related kinases

2. NEK2A Interacts with MAD1 and Possibly Functions as a Novel Integrator of the Spindle Checkpoint Signaling

3. Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome Segregation

4. Irreversible Nek2 Kinase Inhibitors with Cellular Activity

5. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

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