Methanocarba Modification of Uracil and Adenine Nucleotides:  High Potency of Northern Ring Conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but Not P2Y6 Receptors

Author:

Kim Hak Sung1,Ravi R. Gnana1,Marquez Victor E.1,Maddileti Savitri1,Wihlborg Anna-Karin1,Erlinge David1,Malmsjö Malin1,Boyer José L.1,Harden T. Kendall1,Jacobson Kenneth A.1

Affiliation:

1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, and Department of Cardiology, Lund University Hospital, SE-221 85...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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