Lithium Ephedrate-Mediated Addition of a Lithium Acetylide to a Ketone: Solution Structures and Relative Reactivities of Mixed Aggregates Underlying the High Enantioselectivities-Reference-Cited by-同舟云学术

Lithium Ephedrate-Mediated Addition of a Lithium Acetylide to a Ketone: Solution Structures and Relative Reactivities of Mixed Aggregates Underlying the High Enantioselectivities

Published:1998-02-22 Issue:9 Volume:120 Page:2028-2038
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Thompson Andrew¹,Corley Edward G.¹,Huntington Martha F.¹,Grabowski Edward J. J.¹,Remenar Julius F.¹,Collum David B.¹

Affiliation:

1. Contribution from the Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja9713791

Reference59 articles.

1. Synthesis of a Series of 4-(Arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

2. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

3. Use of an ephedrine alkoxide to mediate enantioselective addition of an acetylide to a prochiral ketone: asymmetric synthesis of the reverse transcriptase inhibitor L-743,726

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