Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia-Reference-Cited by-同舟云学术

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

Published:2012-01-25 Issue:3 Volume:3 Page:187-192
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Dounay Amy B.¹,Anderson Marie¹,Bechle Bruce M.¹,Campbell Brian M.¹,Claffey Michelle M.¹,Evdokimov Artem¹,Evrard Edelweiss¹,Fonseca Kari R.¹,Gan Xinmin¹,Ghosh Somraj¹,Hayward Matthew M.¹,Horner Weldon¹,Kim Ji-Young¹,McAllister Laura A.¹,Pandit Jayvardhan¹,Paradis Vanessa¹,Parikh Vinod D.¹,Reese Matthew R.¹,Rong SuoBao¹,Salafia Michelle A.¹,Schuyten Katherine¹,Strick Christine A.¹,Tuttle Jamison B.¹,Valentine James¹,Wang Hong¹,Zawadzke Laura E.¹,Verhoest Patrick R.¹

Affiliation:

1. Pfizer Worldwide Research and Development, Neuroscience Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml200204m

Reference35 articles.

1. The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications

2. A Glycine Site Associated with N-Methyl-d-Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists

3. Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling