Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship-Reference-Cited by-同舟云学术

Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Published:2006-06-10 Issue:14 Volume:49 Page:4425-4436
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wishka Donn G.¹,Walker Daniel P.¹,Yates Karen M.¹,Reitz Steven C.¹,Jia Shaojuan¹,Myers Jason K.¹,Olson Kirk L.¹,Jacobsen E. Jon¹,Wolfe Mark L.¹,Groppi Vincent E.¹,Hanchar Alexander J.¹,Thornburgh Bruce A.¹,Cortes-Burgos Luz A.¹,Wong Erik H. F.¹,Staton Brian A.¹,Raub Thomas J.¹,Higdon Nicole R.¹,Wall Theron M.¹,Hurst Raymond S.¹,Walters Rodney R.¹,Hoffmann William E.¹,Hajos Mihaly¹,Franklin Stanley¹,Carey Galen¹,Gold Lisa H.¹,Cook Karen K.¹,Sands Steven B.¹,Zhao Sabrina X.¹,Soglia John R.¹,Kalgutkar Amit S.¹,Arneric Stephen P.¹,Rogers Bruce N.¹

Affiliation:

1. Pfizer Global Research & Development, Eastern Point Road, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0602413

Reference62 articles.

1. Schizophrenia: Diverse Approaches to a Complex Disease

2. Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications

3. Nicotinic acetylcholine involvement in cognitive function in animals

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