Efficient Chemoenzymatic Synthesis of Pelitrexol via Enzymic Differentiation of a Remote Stereocenter
Author:
Affiliation:
1. Pfizer Global Research and Development, Chemical Research and Development, 10578 Science Center Drive, La Jolla, California 92121
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol0602755
Reference6 articles.
1. Results of 2 phase I studies of intravenous (iv) pelitrexol (AG2037), a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, in patients (pts) with solid tumors
2. Synthesis and biological activity of nor- and homo-5,10-dideazatetrahydrofolic acid
3. Automated Enzyme Screening Methods for the Preparation of Enantiopure Pharmaceutical Intermediates
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