Cryo-tomography and 3D Electron Diffraction Reveal the Polar Habit and Chiral Structure of the Malaria Pigment Crystal Hemozoin

Author:

Klar Paul Benjamin12ORCID,Waterman David Geoffrey34ORCID,Gruene Tim5ORCID,Mullick Debakshi6,Song Yun7,Gilchrist James Boris7,Owen C. David7ORCID,Wen Wen8,Biran Idan9,Houben Lothar10ORCID,Regev-Rudzki Neta11,Dzikowski Ron12,Marom Noa13ORCID,Palatinus Lukas2ORCID,Zhang Peijun714,Leiserowitz Leslie9,Elbaum Michael6ORCID

Affiliation:

1. Faculty of Geosciences and MAPEX Center for Materials and Processes, University of Bremen, Klagenfurter Str. 2, 28359 Bremen, Germany

2. Institute of Physics of the Czech Academy of Sciences, Na Slovance 2, 182 21 Prague 8, Czechia

3. STFC, Rutherford Appleton Laboratory, Didcot OX11 0FA, U.K.

4. CCP4, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0FA, U.K.

5. Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria

6. Department of Chemical and Biological Physics, Weizmann Institute of Science, 76100 Rehovot, Israel

7. Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.

8. Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States

9. Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, 76100 Rehovot, Israel

10. Department of Chemical Research Support, Weizmann Institute of Science, 76100 Rehovot, Israel

11. Department of Biomolecular Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel

12. Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, and The Kuvin Center for the Study of Infectious and Tropical Diseases, The Hebrew University-Hadassah Medical School, Jerusalem 9112010, Israel

13. Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States

14. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, U.K.

Funder

Medical Research Council

Israel Science Foundation

Minerva Foundation

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Diamond Light Source

Grantov? Agentura Cesk? Republiky

Wellcome Trust

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Division of Materials Research

Publisher

American Chemical Society (ACS)

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