Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays

Author:

Tannous Rozan1,Shelef Omri1,Gutkin Sara1,David Maya1,Leirikh Thomas1,Ge Liang1,Jaber Qais1ORCID,Zhou Qingyang2,Ma Pengchen23ORCID,Fridman Micha1ORCID,Spitz Urs4,Houk Kendall N.2ORCID,Shabat Doron1ORCID

Affiliation:

1. School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv 69978, Israel

2. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

3. Department of Chemistry, School of Chemistry, Xi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China

4. BIOSYNTH, Rietlistr. 4 Postfach 125 9422 Staad, Switzerland

Funder

Division of Chemistry

Israel Science Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference47 articles.

1. A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes

2. Lampinen, J.; Raitio, M.; Perälä, A.; Kytöniemi, V.; Harinen, R. Comparison of Flash and Glow ATP Assays with Thermo Scientific Varioskan Flash Luminometry. Application Note: AP-MIB-VARIO12–0108; https://assets.thermofisher.com/TFS-Assets/LCD/Application-Notes/D10338~.pdfhttps://assets.thermofisher.com/TFS-Assets/LCD/Application-Notes/D10338~.pdf (accessed 2023-10-02).

3. Chemical and enzymatic triggering of 1,2-dioxetanes. 2: fluoride-induced chemiluminescence from tert-butyldimethylsilyloxy-substituted dioxetanes

4. Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes

5. The emergence of aqueous chemiluminescence: new promising class of phenoxy 1,2-dioxetane luminophores

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