In Silico Discovery of Small Molecule Modulators Targeting the Achilles’ Heel of SARS-CoV-2 Spike Protein-Reference-Cited by-同舟云学术

In Silico Discovery of Small Molecule Modulators Targeting the Achilles’ Heel of SARS-CoV-2 Spike Protein

Published:2023-02-08 Issue:2 Volume:9 Page:252-265
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Wang Qing¹²^ORCID,Meng Fanhao³,Xie Yuting²,Wang Wei²^ORCID,Meng Yumin⁴,Li Linjie⁴,Liu Tao⁵,Qi Jianxun⁴,Ni Xiaodan³,Zheng Sanduo²⁵,Huang Jianhui¹^ORCID,Huang Niu²⁵^ORCID

Affiliation:

1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China

2. National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, No. 7 Science Park Road, Beijing 102206, China

3. Shuimu Biosciences, Zhongguancun Life Science Park, No. 7 Science Park Road, Beijing 102206, China

4. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

5. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China

Funder

Beijing Municipal Science and Technology Commission

Tsinghua University

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.2c01190

Reference79 articles.

1. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

2. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

3. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

4. Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

5. Distinct conformational states of SARS-CoV-2 spike protein

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