Powerful Avidity with a Limited Valency for Virus-Attachment Blockers on DC-SIGN: Combining Chelation and Statistical Rebinding with Structural Plasticity of the Receptor-Reference-Cited by-同舟云学术

Powerful Avidity with a Limited Valency for Virus-Attachment Blockers on DC-SIGN: Combining Chelation and Statistical Rebinding with Structural Plasticity of the Receptor

Published:2023-02-20 Issue:4 Volume:9 Page:709-718
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Porkolab Vanessa¹,Lepšík Martin²³,Ordanini Stefania⁴,St John Alexander⁵,Le Roy Aline¹,Thépaut Michel¹,Paci Emanuele⁶^ORCID,Ebel Christine¹,Bernardi Anna⁴^ORCID,Fieschi Franck¹⁷^ORCID

Affiliation:

1. Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France

2. Univ. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France

3. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam. 2, Prague 6, 166 10, Czechia

4. Universita’ degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy

5. Astbury Centre & School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom

6. Department of Physics and Astronomy “Augusto Righi”, University of Bologna, Via Zamboni, 33, 40126, Bologna, Italy

7. Institut Universitaire de France (IUF), 1 rue Descartes, 75231 Paris, France

Funder

European Regional Development Fund

H2020 Marie Sklodowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.2c01136

Reference48 articles.

1. Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2. Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis

3. DC-SIGN: escape mechanism for pathogens

4. C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors

5. DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

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