Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis-Reference-Cited by-同舟云学术

Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis

Published:2023-12-20 Issue:1 Volume:10 Page:87-103
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Weerawarna Pathum M.¹^ORCID,Schiefer Isaac T.¹^ORCID,Soares Pedro¹,Fox Susan²,Morimoto Richard I.²,Melani Rafael D.³,Kelleher Neil L.¹²⁴^ORCID,Luan Chi-Hao⁵,Silverman Richard B.¹²⁶^ORCID

Affiliation:

1. Department of Chemistry, Chemistry of Life Processes Institute, Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

2. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

3. Department of Chemistry and Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States

4. Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States

5. High Throughput Analysis Laboratory, Chemistry of Life Processes Institute, and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

6. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States

Funder

Illinois Department of Human Services

International Institute for Nanotechnology, Northwestern University

National Institutes of Health

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00213

Reference46 articles.

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2. Amyotrophic Lateral Sclerosis in South-East England: A Population-Based Study

3. ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

4. Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis