Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

Author:

de las Rivas Matilde1,Paul Daniel Earnest James2,Coelho Helena345,Lira-Navarrete Erandi6,Raich Lluis7,Compañón Ismael8,Diniz Ana3,Lagartera Laura9,Jiménez-Barbero Jesús4510ORCID,Clausen Henrik6,Rovira Carme711ORCID,Marcelo Filipa3,Corzana Francisco8ORCID,Gerken Thomas A.2,Hurtado-Guerrero Ramon112ORCID

Affiliation:

1. BIFI, University of Zaragoza, BIFI-IQFR (CSIC) Joint Unit, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza 50018, Spain

2. Departments of Biochemistry, Pediatrics and Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States

3. UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Nova de Lisboa, Caparica 2825-149, Portugal

4. CIC bioGUNE, Bizkaia Technology Park, Building 801A, 48170 Derio, Spain

5. Departament of Organic Chemistry II, Faculty of Science & Technology, University of the Basque Country, Leioa, 48940 Bizkaia, Spain

6. Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, Copenhagen 1165, Denmark

7. Departament de Química Inorgànica i Orgànica (secció de Química Orgànica) & Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain

8. Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, E-26006 Logroño, Spain

9. Instituto de Química Médica, IQM-CSIC, 28006 Madrid, Spain

10. Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 13, 48009 Bilbao, Spain

11. Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys, 23, 08010 Barcelona, Spain

12. Fundación ARAID, 50018 Zaragoza, Spain

Funder

Danmarks Grundforskningsfond

Funda??o para a Ci?ncia e a Tecnologia

National Institute of General Medical Sciences

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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