Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia

Author:

Zhang Kaiming12ORCID,Horikoshi Naoki34,Li Shanshan12,Powers Alexander S.56,Hameedi Mikhail A.47,Pintilie Grigore D.2,Chae Hee-Don8,Khan Yousuf A.69ORCID,Suomivuori Carl-Mikael6,Dror Ron O.6ORCID,Sakamoto Kathleen M.8,Chiu Wah210ORCID,Wakatsuki Soichi47ORCID

Affiliation:

1. MOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China

2. Department of Bioengineering, Stanford University, Stanford, California 94305, United States

3. Life Science Center for Survival Dynamics, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan

4. Department of Structural Biology, Stanford University, Stanford, California 94305, United States

5. Department of Chemistry, Stanford University, Stanford, California 94305, United States

6. Department of Computer Science, Stanford University, Stanford, California 94305, United States

7. Biosciences Division, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States

8. Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, United States

9. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States

10. CryoEM and Bioimaging Division, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States

Funder

Pediatric Cancer Research Foundation

Leukemia and Lymphoma Society

National Institute of General Medical Sciences

Stanford Maternal Child Health Research Institute

Stanford SPARK program

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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