Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of <i>kappa</i>-Opioid Receptor Agonism-Reference-Cited by-同舟云学术

Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism

Published:2022-07-18 Issue:7 Volume:8 Page:948-954
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Shevick Sophia L.¹²^ORCID,Freeman Stephan M.¹²,Tong Guanghu¹,Russo Robin J.³⁴,Bohn Laura M.³^ORCID,Shenvi Ryan A.¹^ORCID

Affiliation:

1. Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

2. Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

3. Department of Molecular Medicine, Scripps Research, 130 Scripps Way, Jupiter, Florida 33458, United States

4. Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, 130 Scripps Way, Jupiter, Florida 33458, United States

Funder

National Center for Advancing Translational Sciences

National Institute on Drug Abuse

National Institute of General Medical Sciences

Skaggs Graduate School

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.2c00442

Reference58 articles.

1. Isolement et analyse structurale du collybolide, nouveau sesquiterpene extrait de Collybia maculata alb. et sch. ex fries (basidiomycetes)

2. Fungal metabolites. Part 45: The sesquiterpenes of Collybia maculata and Collybia peronata

3. Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity

4. Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists

5. Nalfurafine hydrochloride: A new drug for the treatment of uremic pruritus in hemodialysis patients

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3. A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse;European Journal of Medicinal Chemistry;2022-12

4. Synthesis and Reevaluation of (+)- and (−)-Collybolide as kappa-Opioid Receptor Agonists;Synfacts;2022-10-18