O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

Author:

Gonzalez-Rodriguez Edgar12ORCID,Zol-Hanlon Mia13,Bineva-Todd Ganka1,Marchesi Andrea12,Skehel Mark4,Mahoney Keira E.5ORCID,Roustan Chloë6,Borg Annabel6,Di Vagno Lucia14,Kjær Svend6,Wrobel Antoni G.7,Benton Donald J.7,Nawrath Philipp7ORCID,Flitsch Sabine L.8ORCID,Joshi Dhira9,González-Ramírez Andrés Manuel10,Wilkinson Katalin A.1112,Wilkinson Robert J.11121314,Wall Emma C.1516,Hurtado-Guerrero Ramón101718ORCID,Malaker Stacy A.5ORCID,Schumann Benjamin12ORCID

Affiliation:

1. Chemical Glycobiology Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom

2. Department of Chemistry, Imperial College London, W12 0BZ London, United Kingdom

3. Signalling and Structural Biology Lab, The Francis Crick Institute, NW1 1AT London, United Kingdom

4. Proteomics Science Technology Platform, The Francis Crick Institute, NW1 1AT London, United Kingdom

5. Department of Chemistry, Yale University, 275 Prospect Street, 06511 New Haven, Connecticut, United States

6. Structural Biology Science Technology Platform, The Francis Crick Institute, NW1 1AT London, United Kingdom

7. Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT London, United Kingdom

8. Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, M1 7DN Manchester, United Kingdom

9. Chemical Biology Science Technology Platform, The Francis Crick Institute, NW1 1AT London, United Kingdom

10. Institute of Biocomputation and Physics of Complex Systems, University of Zaragoza, 50018 Zaragoza, Spain

11. Tuberculosis Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom

12. Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, 7925 Observatory, Cape Town, South Africa

13. Department of Infectious Diseases, Imperial College London, W12 0NN London, United Kingdom

14. Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, 7925 Observatory, Cape Town, South Africa

15. The Francis Crick Institute, NW1 1AT London, United Kingdom

16. University College London Hospitals (UCLH) Biomedical Research Centre, W1T 7DN London, United Kingdom

17. Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark

18. Fundación ARAID, 50018 Zaragoza, Spain

Funder

Yale University

Gobierno de Aragón

Agencia Estatal de Investigación

Francis Crick Institute

European Regional Development Fund

Wellcome Trust

UCLH Biomedical Research Centre

National Institute of General Medical Sciences

Engineering and Physical Sciences Research Council

Imperial College London

Medical Research Council

NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research

National Institute for Health Research

Rosetrees Trust

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Fundación Agencia Aragonesa para la Investigación y el Desarrollo

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3