Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling

Author:

Yuan Shijia123ORCID,Xia Lisha123,Wang Chenxi123,Wu Fan4,Zhang Bingjie1,Pan Chen5,Fan Zhiran6,Lei Xiaoguang7ORCID,Stevens Raymond C.124,Sali Andrej8910ORCID,Sun Liping1,Shui Wenqing12ORCID

Affiliation:

1. iHuman Institute, ShanghaiTech University, Shanghai 201210, China

2. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Structure Therapeutics, South San Francisco, California 94080, United States

5. National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China

6. Biocreater (WuHan) Biotechnology Co., Ltd, Wuhan 430075, China

7. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

8. Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, California 94143, United States

9. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143, United States

10. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States

Funder

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

ShanghaiTech University

National Natural Science Foundation of China

National Institute of General Medical Sciences

Beijing Municipal Education Commission

Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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