SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals-Reference-Cited by-同舟云学术

SARS-CoV-2 M^pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

Published:2023-03-21 Issue:4 Volume:9 Page:696-708
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Chen Sizhu Amelia¹²,Arutyunova Elena¹²,Lu Jimmy¹²,Khan Muhammad Bashir¹,Rut Wioletta³^ORCID,Zmudzinski Mikolaj³^ORCID,Shahbaz Shima⁴,Iyyathurai Jegan¹²,Moussa Eman W.¹,Turner Zoe¹^ORCID,Bai Bing⁵⁶,Lamer Tess⁷^ORCID,Nieman James A.⁵⁶^ORCID,Vederas John C.⁷^ORCID,Julien Olivier¹^ORCID,Drag Marcin³^ORCID,Elahi Shokrollah⁴^ORCID,Young Howard S.¹^ORCID,Lemieux M. Joanne¹²^ORCID

Affiliation:

1. Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

2. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada

3. Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland

4. Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Alberta T6G 2E1, Canada

5. Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada

6. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada

7. Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada

Funder

Canadian Institutes of Health Research

Government of Alberta

Canada Foundation for Innovation

Narodowe Centrum Nauki

Natural Sciences and Engineering Research Council of Canada

Alberta Innovates

Polish Medical Research Agency

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00054

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