An Efficient and Telescopic Process for Valsartan, an Angiotensin II Receptor Blocker

Author:

Aalla Sampath1,Gilla Goverdhan1,Bojja Yakambram1,Anumula Raghupathi Reddy1,Vummenthala Prabhakar Reddy2,Padi Pratap Reddy3

Affiliation:

1. Research and Development, Integrated Product Development, Dr. Reddy’s Laboratories Limited, Survey No.’s 42, 45, 46, and 54, Bachupally, Qutubullapur, Ranga Reddy District-500 072, Andhra Pradesh, India

2. Department of Chemistry, University College of Science, Osmania University, Hyderabad-500 007, Andhra Pradesh, India

3. Research and Development, Macleods Pharmaceuticals Limited, G-2, Mahakali Caves Road, Shanthi Nagar, Andheri (E), Mumbai - 400 093, Maharashtra, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference11 articles.

1. The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

2. Sealey, J. E.; Laragh, J. H.InHypertension: Pathophysiology, Diagnosis and Management;Laragh, J. H.; Brenner, B. M., Eds.Raven Press:New York, 1990, p1287.

3. Cocolas, G. H.; Delgado, J. N.; Remers, W. A., Eds. InTextbook of Organic Medicinal and Pharmaceutical Chemistry,10th ed.Lippincott-Raven:Philadelphia, NY, 1998, p603.

4. Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

5. Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series

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