Diversity in the Oxidation of Substrates by Cytochrome P450 2D6:  Lack of an Obligatory Role of Aspartate 301−Substrate Electrostatic Bonding

Author:

Guengerich F. Peter1,Miller Grover P.1,Hanna Imad H.1,Martin Martha V.1,Léger Serge1,Black Cameron1,Chauret Nathalie1,Silva José M.1,Trimble Laird A.1,Yergey James A.1,Nicoll-Griffith Deborah A.1

Affiliation:

1. Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire Dorval, Quebec H9H 4P8, Canada

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Reference65 articles.

1. Identification of molecular aggregates containing glycoproteins III, J, K (carboxypeptidase H), and H (Kex2-related proteases) in the soluble and membrane fractions of adrenal medullary chromaffin granules.

2. Guengerich, F. P. (1997) inBiotransformation, Vol. 3, Comprehensive Toxicology(Guengerich, F. P., Ed.) pp 37−68, Elsevier Science Ltd., Oxford.

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