Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids-Reference-Cited by-同舟云学术

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

Published:2015-10-06 Issue:20 Volume:17 Page:4980-4983
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Liao George P.¹²,Abdelraheem Eman M. M.¹³,Neochoritis Constantinos G.¹,Kurpiewska Katarzyna⁴,Kalinowska-Tłuścik Justyna⁴,McGowan David C.²,Dömling Alexander¹

Affiliation:

1. Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands

2. Janssen Infectious Diseases BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium

3. Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

4. Faculty of Chemistry, Jagiellonian University, 3 Ingardena Street, 30-060 Kraków, Poland

Funder

European Federation of Pharmaceutical Industries and Associations

European Commission

Government of Egypt

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.5b02419

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5. Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

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