Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability

Author:

Chen Kai1,Tang Yang2,Wu Meng1,Wan Xiao-Cui1,Zhang Yan-Ni1,Chen Xiao-Xu1,Yu Fei-Qiang1,Cui Zhi-Hui13,Ma Jin-Ming1,Zhou Zhaocai4,Fang Ge-Min1ORCID

Affiliation:

1. School of Life Science, Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China

2. Center of Minimally Invasive Treatment for Tumor, Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Clinical Research Center for Interventional Medicine, School of Medicine, Tongji University, Shanghai 200072, P. R. China

3. State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong 518055, P. R. China

4. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, P. R. China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

State Key Laboratory of Cell Biology, IBCB SIBS CAS

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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