Total Synthesis of K777: Successful Application of Transition-Metal-Catalyzed Alkyne Hydrothiolation toward the Modular Synthesis of a Potent Cysteine Protease Inhibitor-Reference-Cited by-同舟云学术

Total Synthesis of K777: Successful Application of Transition-Metal-Catalyzed Alkyne Hydrothiolation toward the Modular Synthesis of a Potent Cysteine Protease Inhibitor

Published:2016-01-26 Issue:3 Volume:18 Page:492-495
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Kiemele Erica R.¹,Wathier Matthew¹,Bichler Paul¹,Love Jennifer A.¹

Affiliation:

1. Department of Chemistry, 2036 Main Mall, The University of British Columbia, Vancouver, BC, Canada, V6T 1Z1

Funder

Natural Sciences and Engineering Research Council of Canada

University of British Columbia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.5b03535

Reference36 articles.

1. Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

2. Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection

3. Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

4. Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones

5. Identification of Novel Malarial Cysteine Protease Inhibitors Using Structure-Based Virtual Screening of a Focused Cysteine Protease Inhibitor Library

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