1. Department
of Pharmaceutical Chemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8412, Japan
2. Faculty
of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan
3. Center
for Research and Education on Drug Discovery, Hokkaido University, Kita 12, Nishi
6, Kita-ku, Sapporo, 060-0812, Japan