Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling-Reference-Cited by-同舟云学术

Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling

Published:2020-08-04 Issue:16 Volume:22 Page:6573-6577
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Szpera Robert¹,Isenegger Patrick G.¹,Ghosez Maxime¹,Straathof Natan J. W.¹,Cookson Rosa²,Blakemore David C.³,Richardson Paul⁴,Gouverneur Véronique¹^ORCID

Affiliation:

1. Chemistry Research Laboratory, Oxford University, 12 Mansfield Road, Oxford, OX1 3TA, U.K.

2. Medicines Research Centre, GlaxoSmithKline plc, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

3. Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

4. Medicine Design, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States

Funder

Engineering and Physical Sciences Research Council

European Commission

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c02347

Reference26 articles.

1. Resistance of the 2,2,2-trifluoroethoxy aryl moiety to the cytochrome P-450 metabolism in rat liver microsomes

2. Facile synthesis of trifluoroethyl aryl ethers through copper-catalyzed coupling of CF3CH2OH with aryl- and heteroaryl boronic acids

3. Copper-catalyzed oxidative trifluoroethoxylation of aryl boronic acids with CF 3 CH 2 OH

4. Facile and efficient synthesis of fluoroalkyl aryl ethers

5. Facile Access to Fluorinated Aryl and Vinyl Ethers through Copper-Catalysed Reaction of Fluoro Alcohols

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