Construction of a Highly Diastereoselective Aldol Reaction System with l-Threonine Aldolase by Computer-Assisted Rational Molecular Modification and Medium Engineering-Reference-Cited by-同舟云学术

Construction of a Highly Diastereoselective Aldol Reaction System with l-Threonine Aldolase by Computer-Assisted Rational Molecular Modification and Medium Engineering

Published:2020-07-27 Issue:15 Volume:22 Page:5763-5767
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Zheng Wenlong¹,Chen Kaitong¹,Wang Zhe²,Cheng Xiuli²,Xu Gang¹^ORCID,Yang Lirong¹³^ORCID,Wu Jianping¹³^ORCID

Affiliation:

1. Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

2. Huadong Medicine Co Ltd., Hangzhou, Zhejiang 310011, China

3. Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310027, China

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c01792

Reference26 articles.

1. Improving and Inverting Cβ-Stereoselectivity of Threonine Aldolase via Substrate-Binding-Guided Mutagenesis and a Stepwise Visual Screening

2. Cloning and characterization of d-threonine aldolase from the green alga Chlamydomonas reinhardtii

3. Aldolase catalyzed L-phenylserine synthesis in a slug-flow microfluidic system – Performance and diastereoselectivity studies

4. Enzymes useful for chiral compound synthesis: structural biology, directed evolution, and protein engineering for industrial use

5. An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis

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