Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors-Reference-Cited by-同舟云学术

Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors

Published:2020-07-30 Issue:16 Volume:22 Page:6257-6261
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Nilewski Christian¹^ORCID,Michels Theodore D.¹,Xiang Alan X.¹,Packard Garrick K.¹,Sprengeler Paul A.¹,Eam Boreth¹,Fish Sarah¹,Thompson Peggy A.¹,Wegerski Christopher J.¹,Ernst Justin T.¹^ORCID,Reich Siegfried H.¹^ORCID

Affiliation:

1. eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c01944

Reference34 articles.

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2. Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

3. X-Ray crystal structure of rocaglamide, a novel antileulemic 1H-cyclopenta[b]benzofuran from Aglaia elliptifolia

4. Potential of Cyclopenta[b]benzofurans from Aglaia Species in Cancer Chemotherapy

5. Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression

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