Synthesis of Bis-Macrocyclic HCV Protease Inhibitor MK-6325 via Intramolecular sp2–sp3 Suzuki–Miyaura Coupling and Ring Closing Metathesis-Reference-Cited by-同舟云学术

Synthesis of Bis-Macrocyclic HCV Protease Inhibitor MK-6325 via Intramolecular sp2–sp3 Suzuki–Miyaura Coupling and Ring Closing Metathesis

Published:2015-03-10 Issue:6 Volume:17 Page:1533-1536
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Li Hongmei¹,Scott Jeremy P.²,Chen Cheng-yi¹,Journet Michel¹,Belyk Kevin¹,Balsells Jaume¹,Kosjek Birgit¹,Baxter Carl A.²,Stewart Gavin W.²,Wise Christopher²,Alam Mahbub²,Song Zhiguo Jake¹,Tan Lushi¹

Affiliation:

1. Department of Process Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States

2. Department of Process Chemistry, Merck Sharp & Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.5b00418

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5. Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

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