Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189
Author:
Affiliation:
1. Department of Process Chemistry, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.7b00469
Reference25 articles.
1. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
2. Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells
3. Medicinal Chemistry of Nucleoside Phosphonate Prodrugs for Antiviral Therapy
4. Aryloxy Phosphoramidate Triesters as Pro-Tides
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