Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones-Reference-Cited by-同舟云学术

Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones

Published:2017-08-16 Issue:17 Volume:19 Page:4448-4451
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Whitehead Alan¹^ORCID,Zhang Yong¹,McCabe Dunn Jamie,Sherer Edward C.^ORCID,Lam Yu-hong^ORCID,Stelmach John¹,Sun Aaron¹,Shiroda Melisa¹,Orr Robert K.,Waddell Sherman T.¹,Raghavan Subharekha¹

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.7b01930

Reference27 articles.

1. Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

2. Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities

3. Novel pyrrolo[2,3-d]pyrimidine antifolates: synthesis and antitumor activities

4. A New and Efficient Synthesis of Pyrrolo[2,3-d]pyrimidine Anticancer Agents: Alimta (LY231514, MTA), Homo-Alimta, TNP-351, and Some Aryl 5-Substituted Pyrrolo[2,3-d]pyrimidines

5. Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases

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