Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338
Author:
Affiliation:
1. Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b03481
Reference20 articles.
1. In Vitro Activities of Arylomycin Natural-Product Antibiotics against Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
2. Structural and Initial Biological Analysis of Synthetic Arylomycin A2
3. Total Synthesis of Arylomycin A2, a Signal Peptidase I (SPase I) Inhibitor
4. Intramolecular Suzuki-Miyaura Reaction for the Total Synthesis of Signal Peptidase Inhibitors, Arylomycins A2 and B2
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1. Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria;Journal of Medicinal Chemistry;2024-04-10
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3. Asymmetric Synthesis of N-Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated N-Alkyl Amino Esters;Organic Letters;2023-12-05
4. Stretching Peptides to Generate Small Molecule β-Strand Mimics;ACS Central Science;2023-03-15
5. Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics;Journal of the American Chemical Society;2022-07-29
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