Site-Selective Functionalization of Unactivated Allylic C–H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene-Reference-Cited by-同舟云学术

Site-Selective Functionalization of Unactivated Allylic C–H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene

Published:2023-01-02 Issue:1 Volume:25 Page:277-281
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Clanton Nicholas A.¹^ORCID,Wilson Nicolas A.¹,Ortiz Eliezer¹^ORCID,Blumberg Shawn T.²,Frantz Doug E.¹^ORCID

Affiliation:

1. The Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States

2. Department of Pharmaceuticals & Bioengineering, Southwest Research Institute, San Antonio, Texas 78238, United States

Funder

Division of Chemistry

Southwest Research Institute

Bill and Melinda Gates Foundation

University of Texas at San Antonio

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c04145

Reference25 articles.

1. World Malaria Report. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021 (accessed 2022 February 4, 2022).

2. Global Malaria Diagnostic and Artemisinin Treatment Commodities Demand Forecast 2017–2021. 2018. https://unitaid.org/assets/Global-malaria-diagnostic-and-artemisinin-treatment-commodities-demand-forecast-2017-%E2%80%93-2021-Report-May-2018.pdf (accessed 2022 February 3, 2022).

3. High-level semi-synthetic production of the potent antimalarial artemisinin

4. Production of the antimalarial drug precursor artemisinic acid in engineered yeast

5. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

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