Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy-Reference-Cited by-同舟云学术

Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy

Published:2023-01-23 Issue:4 Volume:25 Page:614-618
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Day Aaron J.¹,Jenkins Timothy C.¹,Kischkewitz Marvin¹,Christensen Kirsten E.¹,Poole Darren L.²^ORCID,Donohoe Timothy J.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom

2. Discovery High-Throughput Chemistry, Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom

Funder

Engineering and Physical Sciences Research Council

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c04149

Reference20 articles.

1. Biologically active isoquinoline alkaloids covering 2014–2018

2. Synthesis of substituted isoquinolines utilizing palladium-catalyzed -arylation of ketones

3. Modular Isoquinoline Synthesis Using Catalytic Enolate Arylation and in Situ Functionalization

4. A Versatile Synthesis of Substituted Isoquinolines

5. The Synthesis of 4-Substituted Isoquinoline Derivatives from Diethyl(4-isoquinolyl)borane

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