Biosynthesis of Piperazine-Derived Diazabicyclic Alkaloids Involves a Nonribosomal Peptide Synthetase and Subsequent Tailoring by a Multifunctional Cytochrome P450 Enzyme-Reference-Cited by-同舟云学术

Biosynthesis of Piperazine-Derived Diazabicyclic Alkaloids Involves a Nonribosomal Peptide Synthetase and Subsequent Tailoring by a Multifunctional Cytochrome P450 Enzyme

Published:2022-05-26 Issue:22 Volume:24 Page:4064-4069
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Pham Mai-Truc¹²³^ORCID,Chen Shu-Rong⁴,Liang Suh-Yuen¹,Cheng Yuan-Bin⁴^ORCID,Lin Hsiao-Ching¹²^ORCID

Affiliation:

1. Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan R.O.C

2. Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan R.O.C

3. Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan R.O.C

4. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan R.O.C

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c01516

Reference30 articles.

1. An Evolving Role of Piperazine Moieties in Drug Design and Discovery

2. Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

3. Recent progress toward the asymmetric synthesis of carbon-substituted piperazine pharmacophores and oxidative related heterocycles

4. Further Structurally Constrained Analogues of cis-(6-Benzhydrylpiperidin-3-yl)benzylamine with Elucidation of Bioactive Conformation: Discovery of 1,4-Diazabicyclo[3.3.1]nonane Derivatives and Evaluation of Their Biological Properties for the Monoamine Transporters

5. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: Interaction with dopamine, serotonin, and norepinephrine transporters

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