Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction-Reference-Cited by-同舟云学术

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction

Published:2016-11-01 Issue:22 Volume:18 Page:5888-5891
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Hyde Alan M.¹,Liu Zhijian¹,Kosjek Birgit¹,Tan Lushi¹,Klapars Artis¹,Ashley Eric R.¹,Zhong Yong-Li¹,Alvizo Oscar²,Agard Nicholas J.²,Liu Guiquan³,Gu Xiuyan³,Yasuda Nobuyoshi¹,Limanto John¹,Huffman Mark A.¹,Tschaen David M.¹

Affiliation:

1. Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Codexis Inc., Redwood City, California 94063, United States

3. Shanghai SynTheAll Pharmaceutical Co., Ltd., Jinshan District, Shanghai 201507, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.6b02910

Reference32 articles.

1. Free fatty acid receptors as therapeutic targets for the treatment of diabetes

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4. High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

5. Efficacy and safety of fasiglifam ( TAK ‐875), a G protein‐coupled receptor 40 agonist, in J apanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double‐blind, placebo‐controlled, phase III trial

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