Copper-Catalyzed Hydrodifluoroalkylation of <i>N</i>-benzylacrylamides via Intramolecular 1,4-Hydrogen Atom Transfer: Reaction Development and Mechanistic Insights-Reference-Cited by-同舟云学术

Copper-Catalyzed Hydrodifluoroalkylation of N-benzylacrylamides via Intramolecular 1,4-Hydrogen Atom Transfer: Reaction Development and Mechanistic Insights

Published:2023-04-16 Issue:16 Volume:25 Page:2889-2894
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Zhang Liming¹,Xu Haoran²,Liu Weitao¹,Li Chengwen¹,Zhao Yilin¹,Yan Linhai¹,Liu Yangping¹^ORCID,Cheng Xianchao¹,Xue Xiao-Song²^ORCID,Han Guifang¹^ORCID

Affiliation:

1. Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China

2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Funder

Tianjin Municipal Science and Technology Bureau

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c00860

Reference82 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

2. Fluorine in medicinal chemistry