Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction-Reference-Cited by-同舟云学术

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

Published:2019-05-08 Issue:10 Volume:21 Page:3838-3841
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Qiu Xing¹,Sun Ning²,Kong Ying²,Li Yan²,Yang Xiaobao²^ORCID,Jiang Biao¹²^ORCID

Affiliation:

1. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

2. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Jing Medicine

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b01326

Reference30 articles.

1. Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

2. Dexamethasone Synergizes with Lenalidomide to Inhibit Multiple Myeloma Tumor Growth, But Reduces Lenalidomide-Induced Immunomodulation of T and NK Cell Function

3. Small-Molecule PROTACS: New Approaches to Protein Degradation

4. Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

5. Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

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