Identification of the Azaserine Biosynthetic Gene Cluster Implicates Hydrazine as an Intermediate to the Diazo Moiety
Author:
Affiliation:
1. Department of Chemistry, The University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Funder
Government of Canada
Uehara Memorial Foundation
Michael Smith Foundation for Health Research
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c01229
Reference34 articles.
1. Azaserine, A New Tumour-Inhibitory Substance: Studies with Crocker Mouse Sarcoma 180
2. New antitumor antibiotic, LL-D05139.BETA.. Fermentation. isolation, structure determination and biological activities.
3. Metabolism and action of amino acid analog anti-cancer agents
4. Synthesis, Characterization, and Immunochemical Detection of O6-(Carboxymethyl)-2‘-deoxyguanosine: A DNA Adduct Formed by Nitrosated Glycine Derivatives
5. Direct Alkylation of Deoxyguanosine by Azaserine Leads to O6-Carboxymethyldeoxyguanosine
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