Aryl (β,β′,β″-Trifluoro)-<i>tert</i>-butyl: A Candidate Motif for the Discovery of Bioactives-Reference-Cited by-同舟云学术

Aryl (β,β′,β″-Trifluoro)-tert-butyl: A Candidate Motif for the Discovery of Bioactives

Published:2023-09-08 Issue:37 Volume:25 Page:6802-6807
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Dobson Luca S.¹,Zhang Qingzhi¹,McKay Benjamin A.¹,Oke Oluwayinka¹²,Isanbor Chukwuemeka²^ORCID,Khan Mohd Faheem³^ORCID,Piscelli Bruno A.⁴,Cordes David B.¹^ORCID,Cormanich Rodrigo A.⁴^ORCID,Murphy Cormac D.³^ORCID,O’Hagan David¹^ORCID

Affiliation:

1. School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, U.K.

2. Chemistry Department, University of Lagos, Akoka, Lagos 101245, Nigeria

3. School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland

4. Chemistry Institute, University of Campinas, Monteiro Lobato Street, Campinas, Sao Paulo 13083-862, Brazil

Funder

Research Councils UK

Commonwealth Scholarship Commission

FAPESP

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c02236

Reference43 articles.

1. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

2. Applications of Fluorine in Medicinal Chemistry

3. Lipophilicity Modulations by Fluorination Correlate with Membrane Partitioning

4. Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

5. Janus All‐ Cis 2,3,4,5,6‐Pentafluorocyclohexyl Building Blocks Applied to Medicinal Chemistry and Bioactives Discovery Chemistry

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1. Biotransformation of fluorinated drugs and xenobiotics by the model fungus Cunninghamella elegans;Methods in Enzymology;2024

2. Aryl (β,β,β-Trifluoro)-tert-Butyl: A Candidate Motif for the Discovery of Bioactives;Synfacts;2023-11-15