Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir-Reference-Cited by-同舟云学术

Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir

Published:2023-07-31 Issue:31 Volume:25 Page:5885-5889
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Van Oers Tayla J.¹,Piercey Alexia²,Belovodskiy Alexandr³,Reiz Béla¹^ORCID,Donnelly Bethan L.¹^ORCID,Vuong Wayne¹,Lemieux M. Joanne⁴^ORCID,Nieman James A.³^ORCID,Auclair Karine²^ORCID,Vederas John C.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada

2. Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada

3. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada

4. Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

Funder

Canadian Institutes of Health Research

Canada Foundation for Innovation

Natural Sciences and Engineering Research Council of Canada

Striving for Pandemic Preparedness ? Alberta Research Consortium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c02140

Reference32 articles.

1. Johns Hopkins Coronavirus Resource Center. https://coronavirus.jhu.edu/ (accessed 2022-12-13).

2. World Health Organization (COVID-19). https://covid19.who.int/region/amro/country/ca (accessed 2022-12-13).

3. Government of Canada (Covid-19). https://www.canada.ca/en/public-health/services/diseases/coronavirus-disease-covid-19/vaccines.html (accessed 2022-12-13).

4. Overcoming COVID-19 vaccination resistance when alternative policies affect the dynamics of conformism, social norms, and crowding out

5. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents;European Journal of Medicinal Chemistry;2024-11

2. A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M^pro) of SARS-CoV-2 and MERS-CoV;JACS Au;2024-07-30

3. Single Electron Transfer Reductive Deuteration of Acyl Chlorides for the Synthesis of Deuterated Alcohols with a High Deuterium Atom Economy;Organic Letters;2024-01-18