A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition-Reference-Cited by-同舟云学术

A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition

Published:2024-02-16 Issue:8 Volume:26 Page:1533-1538
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Barron Benedict¹,Edge Colin²,Fenner Sabine¹^ORCID,Shrives Harry³,Sollis Steven³,Whiting Matthew¹^ORCID,Valette Damien¹^ORCID

Affiliation:

1. Drug Substance Development, GSK, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

2. Computational Chemistry, GSK, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

3. Medicinal Chemistry, GSK, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c03694

Reference31 articles.

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2. New Entries toward 3,3-Difluoropiperidines

3. Aminosulfur trifluorides: relative thermal stability [1]

4. Bis(2-methoxyethyl)aminosulfur Trifluoride: A New Broad-Spectrum Deoxofluorinating Agent with Enhanced Thermal Stability

5. Synthesis and in vitro biological evaluation of fluoro-substituted-4-phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates

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