Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide-Reference-Cited by-同舟云学术

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Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Published:2016-04-18 Issue:9 Volume:18 Page:2300-2303
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Nakamura Hugh¹,Yoshida Takuma¹,Tsukano Chihiro¹,Takemoto Yoshiji¹

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Japan Society for the Promotion of Science

Meiji Seika Pharma Co., Ltd.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.6b00943

Reference51 articles.

1. Novel semisynthetic antibiotics from caprazamycins A–G: caprazene derivatives and their antibacterial activity

2. WHO. Global tuberculosisreport (2015.

3. Caprazamycin B, a Novel Anti-tuberculosis Antibiotic, from Streptomyces sp.

4. Caprazamycins, Novel Lipo-nucleoside Antibiotics, from Streptomyces sp.

5. Inhibition of the First Step in Synthesis of the Mycobacterial Cell Wall Core, Catalyzed by the GlcNAc-1-phosphate Transferase WecA, by the Novel Caprazamycin Derivative CPZEN-45

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