Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate δ-Ester Modifications as Selective Agonists of the P2Y4 Receptor-Reference-Cited by-同舟云学术

Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate δ-Ester Modifications as Selective Agonists of the P2Y4 Receptor

Published:2011-05-20 Issue:12 Volume:54 Page:4018-4033
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Maruoka Hiroshi¹,Jayasekara M. P. Suresh¹,Barrett Matthew O.²,Franklin Derek A.²,de Castro Sonia¹,Kim Nathaniel¹,Costanzi Stefano³,Harden T. Kendall²,Jacobson Kenneth A.¹

Affiliation:

1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States

2. Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States

3. Laboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101591j

Reference45 articles.

1. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

2. P2 Receptors Activated by Uracil Nucleotides - An Update

3. Pharmacological characterization of the human P2Y4 receptor

4. Structure–activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors

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