Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood-Reference-Cited by-同舟云学术

Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood

Published:2013-11-05 Issue:21 Volume:56 Page:8561-8578
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Baur Benjamin¹,Storch Kirsten¹,Martz Kathrin E.¹,Goettert Marcia I.¹,Richters André²,Rauh Daniel²,Laufer Stefan A.¹

Affiliation:

1. Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

2. Department of Chemistry and Chemical Biology, Technical University of Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401276h

Reference35 articles.

1. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis

2. ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

3. The use of TNF-α blocking agents in rheumatoid arthritis: an overview

4. p38MAPK: stress responses from molecular mechanisms to therapeutics

5. Structural basis of inhibitor selectivity in MAP kinases

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