Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase-Reference-Cited by-同舟云学术

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Published:2009-12-17 Issue:3 Volume:53 Page:1048-1055
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boxer Matthew B.¹,Jiang Jian-kang¹,Vander Heiden Matthew G.²³,Shen Min¹,Skoumbourdis Amanda P.¹,Southall Noel¹,Veith Henrike¹,Leister William¹,Austin Christopher P.¹,Park Hee Won⁴⁵,Inglese James¹,Cantley Lewis C.³⁶,Auld Douglas S.¹,Thomas Craig J.¹

Affiliation:

1. NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370 Bethesda, Maryland 20850

2. Dana Farber Cancer Institute, Boston, Massachusetts 02115

3. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115

4. Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada M5G 1L5

5. Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada M5S 1A8

6. Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901577g

Reference29 articles.

1. On the Origin of Cancer Cells

2. On Respiratory Impairment in Cancer Cells

3. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

4. Pyruvate kinase type M2 and its role in tumor growth and spreading

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